Betnovate-N Cream Usage And Safety
Dosage
Betamethasone Valerate, Neomycin Sulphate
Side Effects
Local hypersensitivity , Hypothalamic-pituitary adrenal (HPA) axis suppression , Cushingoid features (e.g. moon face, central obesity), delayed weight gain/growth retardation in children, osteoporosis, glaucoma,hyperglycaemia/glucosuria, cataract, hypertension, increased weight/obesity, decreased endogenous cortisol levels .
Drug Interactions
CYP3A4 inhibitors (e.g. ritonavir, itraconazole) , neomycin sulphate.
Indication
Betamethasone valerate is a potent topical corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses.
When not to Use
Betamethasone valerate-neomycin sulphate is contraindicated in children under 2 years of age. Due to the known ototoxic and nephrotoxic potential of neomycin sulphate, the use of betamethasone valerate-neomycin sulphate in large quantities or on large areas for prolonged periods of time is contraindicated in circumstances where significant systemic absorption may occur.
Betnovate-N Cream Warnings
Warning 1
Betamethasone valerate-neomycin sulphate should be used with caution in patients with a history of local hypersensitivity to betamethasone, neomycin or to any of the excipients in the preparation.
Warning 2
If prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further.
Warning 3
In comparison with adults, children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic adverse effects.
