Side Effects
Common: Dry mouth.Uncommon: Dizziness, headache, taste disorders, vision blurred, atrial fibrillation, pharyngitis, dysphonia, cough, gastro-oesophageal reflux disease, constipation, oropharyngeal candidiasis, rash, dysuria and urinary retention.Rare: Insomnia, glaucoma, intraocular pressure increased, supraventricular tachycardia, tachycardia, palpitations, bronchospasm, epistaxis, laryngitis, sinusitis, intestinal obstruction, including ileus paralytic, gingivitis, glossitis, dysphagia, stomatitis, nausea, urticaria, pruritus, hypersensitivity (including immediate reactions), angioedema and urinary tract infection.Not Known: Dehydration, dental caries, anaphylactic reaction, skin infection, skin ulcer, dry skin and joint swelling.
Drug Interactions
Sympathomimetics, Methylxanthines, Steroids : Tiotropium has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, and oral and inhaled steroids without increase in adverse reactions.Anticholinergics : There is potential for an additive interaction with concomitantly used anticholinergic medications. Therefore, avoid coadministration of tiotropium with other anticholinergic-containing drugs as this may lead to an increase in anticholinergic adverse effects.
Indication
Tiotropium is indicated for the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Tiotropium is indicated to reduce exacerbations in COPD patients .
