Usage And Safety
Dosage
Clindamycin , Benzoyl Peroxide
Side Effects
Mild local irritation , headache . Reports of diarrhoea and colitis ( discontinue immediately) .
Drug Interactions
No formal drug-drug interaction studies have been conducted with clindamycin/benzoyl peroxide gel. Clindamycin/benzoyl peroxide should not be used in combination with erythromycincontaining products due to possible antagonism to the clindamycin component. Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, clindamycin/benzoyl peroxide should be used with caution in patients receiving such agents. Concomitant application of clindamycin/benzoyl peroxide with tretinoin, isotretinoin and tazarotene should be avoided since benzoyl peroxide may reduce their efficacy and increase irritation. If combination treatment is required, the products should be applied at different times of the day (e.g. one in the morning and the other in the evening.). Using topical benzoyl peroxide-containing preparations at the same time as topical sulphonamide-containing products may cause skin and facial hair to temporarily change colour (yellow/orange).
Indication
Clindamycin/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.
When not to Use
Clindamycin/benzoyl peroxide is contraindicated in: Patients who have demonstrated hypersensitivity to lincomycin, clindamycin, benzoyl peroxide or any components of the formulation. Patients with, or with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis (including pseudomembranous colitis).
Warnings
Warning 1
Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy may occur, which sometimes may be severe, especially with the use of peeling, desquamating, or abrasive agents.
Warning 2
If severe local irritancy (e.g. severe erythema, severe dryness and itching, severe stinging/burning) occurs, clindamycin/benzoyl peroxide should be discontinued.
Warning 3
As benzoyl peroxide may cause increased sensitivity to sunlight, sunlamps should not be used and deliberate or prolonged exposure to sunlight should be avoided or minimised. When exposure to strong sunlight cannot be avoided, patients should be advised to use a sunscreen product and wear protective clothing.
